| Component = | Process = | Orthologs = }}High-molecular weight kininogen (HMWK), also known as the Williams-Fitzgerald-Flaujeac factor or the Fitzgerald factor or the HMWK-kallikrein factor is a protein from the blood coagulation system as well as the kinin-kallikrein system. It is a protein that adsorbs to the surface of biomaterials that come in contact with blood in vivo. This protein circulates throughout the blood and quickly adsorbs to the material surfaces. Nomenclature High-molecular weight kininogen is one of the kininogens, a class of proteins. As with many other coagulation proteins, the protein was initially named after the patients in whom deficiency was first observed. When the clinical data were combined, it turned out that all patients in fact had a deficiency of the same protein. Physiology HMWK is one of

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