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What is it? Sparfloxacin (spar FLOX a sin), trade names ZagamŽ and Zagam
Respipac, is a fluoroquinolone antibiotic used in the treatment of
bacterial infections. Zagam is no longer available in the United States.
Pharmacological Properties: Sparfloxacin is about 37- 45% bound to
proteins in the blood(Shimada et at., 1993; Montay,1996).
ˇ Sparfloxacin achieves a high degree of penetration into most tissues,
except for the central nervous system.
ˇ Following a single 400 mg oral dose of sparfloxacin, the mean peak
concentration in cantharides-induced inflammatory fluid is 1.3 lA-g per ml
after a mean duration of 5 h post-dose. Thus(overall sparfloxacin
penetration into inflammatory fluid is 117% and the mean elimination
half-life from this fluid is 19.7 h (Johnson et at., 1992).
ˇ Skin penetration of sparfloxacin is good with skin:plasma ratios of 1.00
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